Written by Laima Hareer | Thursday, 26 May 2022
Whilst ‘gut health’ is not clearly defined in scientific literature, the term has become an increasingly popular concept in modern medicine and the food industry.
Gut health is undoubtedly complex encompassing both the upper and lower gastrointestinal tracts. It is core to overall health and involves five major criteria:
Your gut microbiome (also termed microbiota) is home to hundreds of microbial cells (bacteria, viruses, and fungi) that happily coexist in your small and large intestines. These ‘bugs’ are uniquely diverse, have their own DNA, and are susceptible to change depending on one’s diet, environment, medication intake, and more. The gut microbiome starts evolving from birth with rapid changes taking place in the first two to three years of life. These early changes are predominantly dependent on two things:
After three years the infant microbiome becomes the blueprint of the adult microbiome.
Over recent years the gut microbiome has become a hot topic of research, mostly due to the accruing links to a plethora of health conditions. The microbiome can harbor both beneficial and harmful (at varying levels) microbes. Microbes have the ability to use what you consume (food) as a source of fuel and in turn produce certain metabolites such as short-chain fatty acids, gases, and vitamins. Short-chain fatty acids such as butyrate, propionate, and acetate have particularly key roles in influencing various body systems e.g., immune, nervous, and cardiovascular.
Gut microbiome exploration is an ongoing endeavour. Thus far we only have gained a drop of knowledge when it comes to the sea of microbes within the human gut. What constitutes a healthy microbiome is subjective. One person’s considered ‘healthy’ microbiome may not be healthy for another person. A collective understanding among researchers is that ‘good’ microbes need a good amount of fibre as a fuel source. Increased dietary fibre intake has been long-established as an integral nutrient/ingredient with various health benefits. Hence, it comes as no surprise that our ‘bugs’ love fibre too. Low fibre diets have been linked with an altered gut microbiome composition including a reduction in beneficial bacteria and an increase in the production of not so beneficial metabolites.
Thanks to rapid advances in microbiome testing technology, testing the microbiome has not only become affordable but also easily accessible. Most companies supply at-home non-invasive testing kits that require a small amount of faecal load. Microbiome testing involves elevated levels of DNA sequencing technology. Your poo has quite the potential; it can tell you a lot about your inner workings, i.e., how your gut microbes may behave, what they love to eat, and ultimately what they can produce. Shotgun metagenomics is top tier when it comes to microbiome analysis followed by meta-transcriptomics and metabolomics:
Whilst these tests are not diagnostic per se, they do supply great insight into the community of microbes that exist within you. Each approach in its singular sense provides a substantial amount of information, and a significantly more comprehensive picture when combined. Combined testing is not readily available yet, but it is something to be pursued from both a clinical and research lens.
Bischoff, S. (2011). ‘Gut health’: a new objective in medicine. BMC Med, 9:24. doi: 10.1186/1741-7015-9-24
Cronin, P., Joyce, S., O’Toole, P., & O’Connor, E. (2021). Dietary Fibre Modulates the Gut Microbiota. Nutrients, 13, 1655. doi: 10.3390/nu13051655
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Laima is a highly motivated and enthusiastic evidenced-based integrative health practitioner who is dedicated to helping people restore balance in their lives through natural and nutritional remedies. As a clinical Naturopath with both industry and academic experience, Laima has mentored practitioners, students, and successfully treated patients in acute and chronic settings.
Laima is currently taking a break from completing her Masters in Nutrition and Dietetic Practice, as well as a Post-Graduate degree in Neuroscience and Mental Health. She is currently mentoring Endeavour students on their clinical placements as well as working in collaboration with a biotechnology company, as part of the science research and product innovation team; focusing on microbiome health advancements.