An Australian research team will be conducting a world-leading study examining a diagnostic test used by health professionals internationally. The test is claimed to measure the urine level of biomarkers, known as kryptopyrroles, but a scarcity of research has raised questions about the clinical significance of the test.

  • 3 minutes
  • 05 February 2018

The research, led by Endeavour College of Natural Health’s Office of Research, is the first study of its kind internationally.

“We know health professionals have been using urinary kryptopyrrole (UKP) testing for a number of years to better understand the biochemistry of their more complex patients, but to date there has been no scientific examination of the clinical significance of this test. Our research project will provide the most detailed examination of UKP testing ever conducted in the world,” said Associate Director Research for Endeavour College of Natural Health and research fellow with ARCCIM at the University of Technology Sydney, Dr Amie Steel.

“Our study will have three different stages through which we will be able to draw on the experience and knowledge of clinicians who are already using the test, as well as observe the links between elevated urinary kryptopyrroles and individual health conditions.”

The three stages of the project consist of a survey of clinicians who have used the test to capture their experience of UKP testing in a clinical setting. The study will also measure the UKP levels of a mix of individuals from the general community who are either healthy or have a diagnosed health condition. The third stage will invite patients, as seen by clinicians who have experience using UKP testing, to have their test results shared with the research team for analysis.

Dr Steel said that, despite the widespread use of the test, very little research had been conducted to date. As such, the multiple stages of the project were needed to ensure that the breadth of experience among clinicians who have been using the test is included in the study design.

“We acknowledge that, while the test itself has not been studied systematically to the level we would expect, clinicians have been observing its strengths and weaknesses in their own practice. We want to make sure that we are building on that knowledge and expertise.”

The study is sponsored by SAFE Analytical Laboratories, a testing company which has provided clinicians with urinary kryptopyrrole testing services. “As an organisation we identified important questions without adequate answers and knew that if we did not get behind progressing research on the topic then the gaps would remain,” said Quality Assurance Manager for SAFE Analytical Laboratories Mr Peter Toh. “We are committed to providing the highest quality services to our customers and so we saw this as an opportunity to support clinicians with better information.”

More information about the research project, which will run throughout 2018, can be found here:

About Endeavour College of Natural Health’s Office of Research

Endeavour’s Office of Research is dedicated to strengthening professional practice for complementary medicine professionals through an expanded body of evidence-based research for complementary medicine in Australia. It works to disseminate and critically examine all aspects of contemporary complementary medicine practice through the application of non-partisan, rigorous, and robust empirical research.

The Office of Research is an arm of Endeavour College of Natural Health, Australasia’s largest degree conferring tertiary institution offering qualifications in complementary medicine and natural health. It has six campuses in Australia and two in New Zealand, five Bachelor degrees, four Honours degrees, 5,000 students, 350 staff and leading academics in the field.

For further information or to set up an interview with Dr Amie Steel please contact:
Rebecca Reid: +61 7 3253 9582 or