Endeavour Funded Projects

The following projects have been funded by Endeavour through the Endeavour Research Grant Program.

Natural Exportin 1 (XPO1) inhibitors as antiviral agents against Respiratory Syncytial Virus (RSV)

Chief investigator: Professor Reena Ghildyal
Affiliated institutions: University of Canberra
Grant value: $21,000
Expected completion: 20 August 2019

Human Respiratory Syncytial Virus (RSV) is the major cause of respiratory tract infections in infants, young children, elderly and the immune compromised. RSV infection in early childhood accounts for substantial morbidity and mortality and is associated with chronic asthma and recurrent wheezing later in life. Antiviral activities have been reported for numerous medicinal plants that have been used extensively as part of traditional medicine for centuries. Herbal products with confirmed clinical safety features are attractive starting material for the identification of new antiviral applications. This study aims to screen natural compounds with in order to identify suitable drug candidates for development against RSV disease.

Examining complementary medicine practitioners’ approaches to weight loss

Chief investigator: Dr Romy Lauche
Affiliated institutions: University of Technology (Sydney), University of Sydney
Grant value: $10,256
Expected completion: 20 August 2018

Most people with overweight and obesity have a desire to lose weight, and might consult health care providers including complementary medicine (CM) practitioners for advice or assistance. This study will combine an online survey and qualitative interviews to examine CM practitioners’ weight loss approaches used by CM practitioners to provide a better understanding of the role of CM for weight loss in contemporary health care, and lay a foundation for future research evaluating efficacy and safety of those interventions that can benefit patients with overweight and obesity.

Integration of 3D models into biosciences curriculum delivered at Endeavour College of Natural Health to enhance student learning outcomes

Chief Investigators: Associate Professor Goran Strkalj
Affiliated institutions: Macquarie University
Grant value: $2,700
Expected completion: 20 August 2017

Education in the biosciences has in recent years been characterized by the efficient application of modern technologies. One of the most prominent of these has been the use of three dimensional (3D) printing. The overall objective of this project is integration of specific 3D models into bioscience curriculum and investigation of its impact on student learning outcomes. This study will deliver 3D models of both macroscopic and microscopic structures, integrate 3D models into the one biosciences subject delivered at Endeavour College of Natural Health (BIOH111) as a targeted educational intervention and assess learning outcomes that resulted from integration of the intervention.

Effect of milk thistle extract (Silibinin) on circulating unconjugated bilirubin levels and markers for oxidative stress and inflammation: MOJO Study

Chief investigator: Dr Michael Watson
Affiliated institutions: Griffith University
Grant value: $14,000
Expected completion: 20 August 2018

Milk Thistle has been used in medical remedies for 2000 years as a therapeutic herbal medicine in the treatment of acute and chronic liver diseases. Some of its effects have been shown to be due to an antioxidant and anti-inflammatory action. Currently, there are no clinical studies on the effect of milk thistle extract on health volunteers and in those at risk of cardiovascular disease (CVD). This pilot study will examine the effect of short term (21 day) administration of the Milk Thistle extract, Legalon® on bilirubin levels and markers of CVD in healthy volunteers.

Complementary and alternative medicine (CAM) and nurses: Improving patient safety through communication and collaboration

Chief investigator: Dr Helen Hall
Affiliated institutions: Monash University, University of South Australia, University of Newcastle
Grant value: $13,991
Expected completion: 21 August 2017

This project is the first national study in Australia to investigate the barriers and enablers to nurses’ communication and referral patterns regarding CAM. The aims of this project is to identify the barriers and enablers to open CAM communication between nurses and patients and to identify the barriers and enablers to nurses referring patients to CAM practitioners. The results of this study will be used to inform nursing education and practice, regarding CAM communication and referral to CAM providers and to support the development of a communication / referral tool for nurses working in Australia.

Student happiness and intrinsic academic motivation: Informing future policy for retention and engagement of tertiary students

Chief investigator: Mr Mark Payne
Affiliated institutions: Endeavour College of Natural Health
Grant value: $1,010
Expected completion: 21 August 2016

It is hypothesized that students who demonstrate a higher level of perceived happiness will demonstrate a higher level of intrinsic motivation to engage in their studies, and will sustain or increase their perceived level of happiness over time. By comparison students with a low level of perceived happiness will demonstrate a low level of engagement in their studies and a decreasing level of happiness over time. Therefore the aim of this study is to measure subjective happiness in tertiary students over time and correlate this with a measurement of positive intrinsic motivation to remain engaged with their studies. A secondary aim will be to determine whether happiness over time increases, decreases or remains stable whilst undertaking tertiary level studies. The result of this study will be used to inform future policy development on the importance and role of happiness in sustaining student's intrinsic motivation to engage with their studies.

The utilisation of complementary and alternative medicine for children: A mixed methods study to examine parental attitudes and information sources

Chief investigator: Dr Jane Frawley
Affiliated institutions: University of Technology (Sydney)
Grant value: $3,000
Expected completion: 31 August 2015

The objective of this project is to explore parental decision-making in relation to health care options and services for their children, including complementary and alternative medicine (CAM) services and products. This project will address significant information gaps in relation to parent’s decision-making process by examining key information sources utilised as well as parental attitudes to CAM use for their children.

A naturalistic observational study of Western herbal medicine practice

Chief investigator: Dr Jonathon Wardle
Affiliated institutions: University of Technology (Sydney)
Grant value: $13,400
Expected completion: 31 August 2016

The project is a naturalistic observational study of individualised Western herbal medicine in a naturopathic practice setting. This project will explore the effectiveness of individualised herbal medicines in multiple conditions, using a whole practice framework. This approach will not only help to evaluate total herbal medicine practice rather than individual herbal medicines in specific conditions, but will also help to develop research capacity on the practitioners community.

The Integrative health care Model development and Evaluation [TIME] project – Phase 1 needs analysis and Phase 2 model development

Chief investigator: Dr Matthew Leach
Affiliated institutions: University of South Australia, Flinders University
Grant value: $9,000
Expected completion: 31 August 2016

Integrative health care (IHC) is a comprehensive and holistic approach to health care in which all health providers work collaboratively, including biomedical and complementary medicine professionals, in an equal and respectful manner, to safely and effectively meet the needs of the consumer and broader community. Interest in this model of care has escalated over the past few decades, leading to a global growth in the number of IHC centres, practitioners, associations, publications and training programs. However, despite the growth in IHC, few have questioned whether this approach is appropriate or acceptable; even fewer have explored how IHC should be administered, especially from a consumer or provider viewpoint. To address this gap, and in turn, develop a more suitable and theoretically grounded framework for IHC, the project will: explore consumer and health stakeholder perspectives of IHC through focus groups (stage 1), a systematic review (stage 2) and a national survey (stage 3), and; utilise findings from stages 1-3 to develop an IHC service delivery model (stage 4). Findings from the project will be leveraged into a larger competitive research grant to implement (stage 5) and evaluate (stage 6) the effectiveness of the IHC model in primary care.

Completed Grant Projects

Women's reasons, perceptions, and expectations of consultation with acupuncturists and use of acupuncture for menopausal symptoms

Chief investigator: Dr Wenbo Peng
Affiliated institutions: University of Technology (Sydney)
Grant value: $2,800
Expected completion: 3 February 2016

Most mid-age women need to seek medical advice for relieving menopausal symptoms. Acupuncture constitutes a popular treatment option amongst these women. Despite the positive findings regarding the efficacy of acupuncture for menopausal symptoms, there has been no in-depth study on menopausal women's reasons, perceptions and expectations of both acupuncture use and acupuncturists’ consultation. The proposed project will address this important research gap by identifying the role of acupuncturists in the overall support from the patient perspective, and exploring the underlying decision-making process of acupuncture use for specific menopausal symptoms in Australia.